WP 3.18: Impact of Breast Reconstruction and Oncoplastic Surgery on Breast cancer-related lymphedema, Quality of Life and Patient Satisfaction: A Prospective Observational Study

Breast cancer incidence has risen in Denmark, with survival rates improving to 88% over five years due to advancements in treatment. Consequently, a growing number of women live with late effects, including lymphedema and reduced quality of life. While 40% of women undergo
reconstruction post-mastectomy and 27.5% opt for oncoplastic surgery, limited data exists on how these procedures impact lymphedema risk and long-term physical and psychosocial outcomes. This project aims to address these gaps through three interconnected studies.
The first study investigates the relationship between breast reconstruction or oncoplastic surgery and lymphedema risk via systematic reviews and meta-analyses. The second study focuses on psychometric validation of seven BREAST-Q modules in Danish, including domains like cancer worry, breast sensation, and work impact. The third study evaluates lymphedema incidence and quality of life over time among women undergoing different types of breast surgery, using data from existing cohorts and validated tools like the LYMPH-Q and BREAST-Q.
By integrating advanced methodologies and patient-reported outcome measures, this project aims to establish evidence-based guidelines for reducing complications, improving surgical outcomes, and enhancing quality of life. The findings will inform clinical practice and public health strategies, benefiting breast cancer survivors in Denmark and beyond.

Awarded to: Tine Engberg Damsgaard (University Hospital of Southern Denmark (SLB-Vejle) and Odense University Hospital) – CFA3

Awarded grant to support VIP personnel.